Prime Behavior Testing Laboratories Inc. is a US-based company that serves to assist clients with the testing and evaluation of novel therapeutic agents and to identify products that may be suitable for clinical trials in an efficient and cost-effective manner. We specialize in cognition testing (Learning, Memory, and Attention) in rodent and Non-Human Primates (NHPs).
We test the efficacy of novel therapeutics for cognitive and psychiatric disorders. We also test drugs for abuse potential and abuse prevention.
Tests on rodent and Non-Human Primates are overseen by a full-time academic who runs the small animal core facility. We stay current due to ongoing scientific research studies in animal behavior.
PBTLI is unique from most other clinical research organizations - we provide specialized attention and cater our research specifically to your company's needs.
Abstract: Rodent models have facilitated major discoveries in neurobiology, however, the low success rate of novel medications in clinical trials have led to questions about their translational value in neuropsychiatric drug development research. For age-related disorders of cognition such as Alzheimer’ disease (AD) there is interest in moving beyond transgenic amyloid-β and/or tau-expressing rodent models and focusing more on natural aging and dissociating “healthy” from “pathological” aging to identify new therapeutic targets and treatments. In complex disorders such as AD, it can also be argued that animals with closer neurobiology to humans (e.g., nonhuman primates) should be employed more often particularly in the later phases of drug development. The purpose of the work described here was to evaluate the cognitive capabilities of rhesus monkeys across a wide range of ages in different delayed response tasks, a computerized delayed match to sample (DMTS) task and a manual delayed match to position (DMTP) task...